It looks like a large mold so I'd say two clamp minimum. I'd try to keep the clamp pads located at mid mold, from top to bottom, and have one at 1/3 of the length from each end. I'd also be sure to clamp the hinge side first.
Why would you need to shoot the mold at over 350 degrees? It looks like it should shoot real well at between 340 and 320 degrees unless you are splitting colors, then I'd push the second color at about 350 and hold some pressure for about 5 or 6 seconds.