This has been a really good thread, sorry it has had to come at Steve's expense.
Before I go into detail, I am 99.9% positive the air is coming from the injector. Let me explain why:
Here is the pic of your bait from your earlier post:

The entire mold is solid with plastic, except an air bubble in the middle bait.
What does this tell us?
1) It isn't a problem with sucking plastic from the spru / runner (see example in video below). If it was it would be hollow like a straw leading to the bait(s).
2) It isn't a problem with sucking air from the venting. If this was the case the bubble or dent would be close to the vents, not the head of the bait.
3) The venting is working properly. It it wasn't there would be significant back pressure and the ends of the bait (closest to the vents) wouldn't form properly. The tails look good.
4) You're not running out of plastic - all the baits are well formed / complete.
5) The cavities and mold overall all proportioned, clamped and sealing correctly. If this wasn't the case there would be a big dent in the bait near the thickest part of the bait, or near the breach in integrity.
Here is a video that illustrates how to troubleshoot common air problems and how you can address them:
http://youtu.be/Ezj97apmgNcSo what's causing the problem??? There are some small air bubbles in the bait, but there was at least one big bubble that made it's way into the mold as well. Interesting is that it is not in the bait furthest from the spru. This would indicate that the bubble was around 1/2" from the tip of your nozzle (in your injector). I'm not sure how it got there, but I would try the following to get it out.
1) Make sure there are no bubbles in your plastic
2) Once you injector is full, hold it tip up over your cup, allow any air in the injector to rise to the top (this is key given where the bubble is in the mold - give them a chance to rise to the top), and purge. You should see plastic, air, plastic. At this point you should be ready to go.
If you are still having the same problem, I would try a thin walled injector to see if you get the same results.
I know you said you didn't have this problem with other single cavity molds, I would shoot several of them back to back in clear plastic as well, just to verify that you aren't having the same problem and just haven't recognized it, or to rule out a new problem with an o-ring on your injector that is new.
If this problem stays isolated to this one mold, and none of the above helps, let me know and we'll do whatever we need to do to take care of it.
Jason