Nothing made to be involved with these plastic is water-soluble.
X2 colors will settle over long periods but I haven't seen them pack like other colorants do.
I shake my plastic a lot. Often. Opened or other-wise, I shake it. All of my colors have a lead sprue from casting small jigheads inside. Some have two. If you have colors that pack fast and super hard, loosen everything up with a small thin screwdriver and shake the heck out of it, then split it into two different bottles and add some worm oil or raw plastic along with the stainless nuts or lead pellets and continue to shake until the floaters are dissolved.
Colorants will settle faster in some colors than others but that depends on how much pigment is used and what color the pigment is. White is by far the worst color to loosen up in regular colorants. I have a bottle of X2 white that has not packed at all in the more than a year that I have had it and white has more components than any color on earth. Keeping colors mixed all the time is almost an inconceivable task without having agitators working around the clock. Still, the more often you take time to keep things mixed, the more you'll get out of your products. That's just a fact with this stuff and pretty much a bottom line.